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1.
Contact (Thousand Oaks) ; 5: 25152564221119347, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-37366506

RESUMO

Endoplasmic reticulum-mitochondria contact sites regulate various biological processes, such as mitochondrial dynamics, calcium homeostasis, autophagy and lipid metabolism. Notably, dysfunctions in these contact sites are closely related to neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis. However, details about the role of endoplasmic reticulum-mitochondria contact sites in neurodegenerative diseases remain unknown. In Parkinson's disease, interactions between α-synuclein in the contact sites and components of tether complexes that connect organelles can lead to various dysfunctions, especially with regards to calcium homeostasis. This review will summarize the main tether complexes present in endoplasmic reticulum-mitochondria contact sites, and their roles in calcium homeostasis and trafficking. We will discuss the impact of α-synuclein accumulation, its interaction with tethering complex components and the implications in Parkinson's disease pathology.

2.
Braz. J. Pharm. Sci. (Online) ; 58: e18943, 2022. graf
Artigo em Inglês | LILACS | ID: biblio-1364427

RESUMO

Abstract The objective of this study was to evaluate drug interactions based on medical records of patients hospitalized in University Hospital Lauro Wanderley (UHLW) in João Pessoa-PB, Brazil. This was a quantitative, descriptive study with a cross-sectional design. This research was conducted in the medical clinic of the above hospital by analyzing pharmaceutical intervention in medical records. The investigated samples consisted of all medical profiles with drug interaction information of patients hospitalized from June 2016 to June 2017. Most of these drug interactions were determined and classified by Micromedex® Solutions database. This research was approved by the Ethics Committee in Institutional Human Research, protocol number 2.460.206. In total, 331 drug interactions were found in 131 medical profiles. Dipyrone, enoxaparin, sertraline, ondansetron, quetiapine, tramadol, bromopride, amitriptyline, and simvastatin were medications that showed highest interactions. According to Anatomical Therapy Classification (ATC), drugs that act on the central nervous system result in more interactions. The most prevalent interaction was between dipyrone and enoxaparin. Some limitations of this study are the lack of notifications and data on drug interactions.


Assuntos
Humanos , Masculino , Feminino , Pesquisa , Prontuários Médicos/classificação , Interações Medicamentosas , Estudos de Avaliação como Assunto , Pacientes Internados/classificação , Universidades , Preparações Farmacêuticas , Dipirona/efeitos adversos , Enoxaparina/provisão & distribuição , Sinvastatina/provisão & distribuição , Sertralina/provisão & distribuição , Fumarato de Quetiapina/provisão & distribuição , Amitriptilina/provisão & distribuição , Hospitais Universitários/organização & administração
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